This document describes how to install a Postfix mail server that is based on virtual users and domains, i.e. users and domains that are in a MySQL database. I will also demonstrate the installation and configuration of Courier (Courier-POP3, Courier-IMAP), so that Courier can authenticate against the same MySQL database Postfix uses. The resulting Postfix server is capable of SMTP-AUTH and TLS and quota (quota is not built into Postfix by default, I will show how to patch your Postfix appropriately). Passwords are stored in encrypted form in the database (most documents I found were dealing with plain text passwords which is a security risk). In addition to that, this tutorial covers the installation of Amavisd, SpamAssassin and ClamAV so that emails will be scanned for spam and viruses.

http://www.howtoforge.com/virtual-users-and-domains-postfix-courier-mysql-centos5.1